The Department of Infrastructure and Energy (DIE) oversees the implementation of Agenda 2063 infrastructure programs. Additionally, it manages the African Union's (AU) initiatives focused on promoting, coordinating, implementing, and monitoring programs and policies related to infrastructure development, transport, energy resources, information and communications technology (ICT), as well as postal services and tourism at both regional and continental levels.

DIE also facilitates private sector initiatives on infrastructure development and advocating among development partners for programme implementation.

The department is in charge of the following key Agenda 2063 projects: the Single African Air Transport Market (SAATM), the Pan African e-Network (PAeN), the Integrated High Train Network,